Light – Candles And Candle Making http://candlesandcandlemaking.com/ Mon, 23 Aug 2021 01:05:53 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://candlesandcandlemaking.com/wp-content/uploads/2021/05/candles-and-candle-making-icon.png Light – Candles And Candle Making http://candlesandcandlemaking.com/ 32 32 Covid 19: Early end-of-life consultation on the Auckland tram https://candlesandcandlemaking.com/covid-19-early-end-of-life-consultation-on-the-auckland-tram/ https://candlesandcandlemaking.com/covid-19-early-end-of-life-consultation-on-the-auckland-tram/#respond Mon, 23 Aug 2021 00:00:00 +0000 https://candlesandcandlemaking.com/covid-19-early-end-of-life-consultation-on-the-auckland-tram/

The lockdown of the Covid-19 alert level 4 prematurely ended the live public consultation on the Auckland light rail system project.

The Auckland Light Rail Transit (ALR) government unit had scheduled two more live events before the initial consultation ended, ahead of a recommendation in September on the type of program preferred.

“In addition to considering public safety, we need to put the safety and well-being of our team and our communities first,” said Tommy Parker, Managing Director of ALR.

“Face-to-face engagement is no longer appropriate during lockdown. “

READ MORE:
* Auckland light rail train: massive transport project made public after six years
* Railless trams on Dominion Rd in Auckland won’t solve traffic jams, city planner says
* Who exactly will take control of the Auckland tram system?

ALR has hosted 11 live events in the community seeking public opinions since the government announced before Easter the revival of the light rail project.

Parker said ALR would close the consultation primarily online, with workshops for the community and stakeholders, and put more material on social media to encourage public comment.

“We are confident that even with this shift to different channels, our engagement remains strong,” Parker said. Thing in a report.

An artist's impression of how a "modern tram" light rail system would look in the suburbs of Auckland.

ALR / Supplied

An artist’s impression of the appearance of a “modern” tram system in suburban Auckland.

In 2017, the government resumed plans from Auckland for a light rail line from downtown to Mount Roskill, then to Māngere and the airport, but wasted three years weighing competing ideas from the public and private sectors. .

There are no details yet on the proposed plan, with the consultation covering aspects of the previous two ideas, a traditional street-level service, or a more underground and elevated high-speed “metro” system.

The government unit will make a general recommendation on what type of diet it prefers and is expected to announce by Christmas how it will proceed.

Chronology of decision making for Auckland Light Rail.

ALR / Supplied

Chronology of decision making for Auckland Light Rail.

“The project team received over 1,000 responses online and several hundred more during community engagement at markets and events, as well as through workshops and presentations with key groups in the industry and community, ”Parker said.

For a few years the project was promoted as ‘light rail to airport’, but it is now described as serving large redevelopments of state-owned housing in Mt Roskill and Māngere, and increasing housing density. along its route.

A later step could extend a line to Kumeu northwest of the city, but that is not part of the current plan.

Source link

]]>
https://candlesandcandlemaking.com/covid-19-early-end-of-life-consultation-on-the-auckland-tram/feed/ 0
Dying Light 3 looks more likely than Call of Juarez 5 https://candlesandcandlemaking.com/dying-light-3-looks-more-likely-than-call-of-juarez-5/ https://candlesandcandlemaking.com/dying-light-3-looks-more-likely-than-call-of-juarez-5/#respond Sun, 22 Aug 2021 16:02:06 +0000 https://candlesandcandlemaking.com/dying-light-3-looks-more-likely-than-call-of-juarez-5/

Several job postings for the developer of Dying Light 2: Stay Human Techland have shed light on the developer’s next project following the release of his latest game in December – and it seems much more likely to be Dying. Light 3 as a new game in the studio’s fan favorite. Western Call of Juarez FPS series.

Two new positions have opened up at Techland (spotted by Exputer), and both seem to point to the next Dying Light studio game rather than anything for Dying Light 2. The ad for Senior 3D Artist specifically says that it is. is for the studio “next big title”, with the suggestion that it is another triple A title.

However, it is the post of Senior Quest Designer that offers the most intrigue. The “expectations” list asks applicants to have “familiarity with the difference between storytelling and gameplay layer in open-world action RPG games” – suggesting that Techland’s next game will be an RPG from Open-world action with an immersive narrative focus, similar to Dying Light or Dead Island.

The list also intriguingly mentions familiarity with the basics of the Unreal Engine, but it seems unlikely that the studio will abandon their own engine after spending so much time building it for Dying Light 2.

Unfortunately for fans of the Call of Juarez series, this description sounds much closer to another Dying Light-style game than an FPS – unless Techland takes the series in a drastically different direction. The studio reclaimed the rights to Ubisoft’s Call of Juarez series in 2018 following the temporary withdrawal of the latest Gunslinger game from Steam, and fans have been hoping to see a new FPS in the franchise ever since.

I guess they’ll be waiting a bit longer unless Techland has another game up its sleeve.

{“schema”: {“page”: {“content”: {“headline”: “Dying Light 3 seems more likely than Call of Juarez 5”, “type”: “news”, “category”: “dying-light -2 “},” user “: {” loginstatus “: false},” game “: {” publisher “:” Techland Publishing “,” genre “:” Survival “,” title “:” Dying Light 2 “,” genres “:[“Survival”,”FPS”]}}}}

Source link

]]>
https://candlesandcandlemaking.com/dying-light-3-looks-more-likely-than-call-of-juarez-5/feed/ 0
Archaeological evidence sheds new light on early human presence in western Iran https://candlesandcandlemaking.com/archaeological-evidence-sheds-new-light-on-early-human-presence-in-western-iran/ https://candlesandcandlemaking.com/archaeological-evidence-sheds-new-light-on-early-human-presence-in-western-iran/#respond Sun, 22 Aug 2021 05:04:42 +0000 https://candlesandcandlemaking.com/archaeological-evidence-sheds-new-light-on-early-human-presence-in-western-iran/

TEHRAN – Newly discovered stone tools and animal remains have shed new light on the history of human presence in Paveh County, Kermanshah Province, in western Iran.

Based on new archaeological findings, the history of human habitation in Paveh County, located in southern Hawraman (Uramanat), is estimated to date back more than 40,000 years, the provincial tourism chief said. Jabbar Gohari in an interview. with Salam Paveh last week.

The survey was carried out near the villages of Shamshir and Zardui, in the south of the Hawraman region, with the close cooperation of archaeologists from the Paleolithic department of the Iranian National Museum and the Department of Cultural Heritage, Tourism and Culture. Kermanshah crafts, the official said.

Gohari added that recent archaeological finds in the area hold promise for further studies on Hawraman’s prehistory. Referring to the preliminary results of this archaeological reconnaissance, Gohari said the human history of the area is much older than previously thought.

“Based on these recent findings, the history of human habitation in Paveh County dates back over 40,000 years and this early evidence adds to the richness and importance of the Hawraman region of Kermanshah. “

“Paleolithic hunters used two rock shelters for seasonal or short-term habitation near the villages of Shamshir and Zardui during a period that archaeologists call the Middle Paleolithic,” the official explained.

According to the archaeologists involved in this research, the inhabitants of these two shelters, most likely Neanderthals, used flint to produce stone tools, which according to their type and method of chipping (like Levallois technology) belong to the Middle Paleolithic. (40,000 to 200,000 years ago), Gohari added.

In addition to stone tools, the presence of animal remains such as fragments of bones and teeth in these shelters, which mostly belong to ibex, can provide a window to study the ancient biodiversity of the area during the ice age, he said.

Gohari pointed out that Middle Paleolithic human remains were found in several shelters in the Sirwan River Valley near Hajij (Hawraman) during the Darian Dam archaeological recovery program, which was carried out under the direction of Fereidoun Biglari in 2015.

In July, UNESCO added Uramanat Cultural Landscape to its list of World Heritage sites. The United Nations body accepted the landscape, which is home to hundreds of villages, 106,000 hectares of land and 303,000 hectares of surrounding properties, at the 44th session of the World Heritage Committee, held in Fuzhou in China.

Stretching on the slopes of Sarvabad County and shared between Kordestan and Kermanshah provinces, the rural area embraces rows of dense, stepped houses such that the roof of each house forms the courtyard of the tallest one, a characteristic feature. which adds to its charm and appeal.

AFM

Source link

]]>
https://candlesandcandlemaking.com/archaeological-evidence-sheds-new-light-on-early-human-presence-in-western-iran/feed/ 0
Sailing boats and bicycle rickshaws in the oil-rich, fuel-efficient region of Venezuela https://candlesandcandlemaking.com/sailing-boats-and-bicycle-rickshaws-in-the-oil-rich-fuel-efficient-region-of-venezuela/ https://candlesandcandlemaking.com/sailing-boats-and-bicycle-rickshaws-in-the-oil-rich-fuel-efficient-region-of-venezuela/#respond Wed, 11 Aug 2021 01:26:18 +0000 https://candlesandcandlemaking.com/sailing-boats-and-bicycle-rickshaws-in-the-oil-rich-fuel-efficient-region-of-venezuela/

Maracaibo (Venezuela) (AFP)

Maracaibo is known as the center of Venezuela’s oil industry, but a chronic fuel shortage has forced fisherman Franklin Romero to use a sailboat and bus driver Manuel to work in a pedicab.

Venezuela has the largest proven oil reserves in the world, but has gone from a peak production of over three million barrels of crude a day in 2014 to just over 500,000 today, meaning that the country needs to import fuel.

Experts accuse the government of President Nicolas Maduro of incompetent management and corruption.

Under the scorching sun in the state of Zulia, northwestern Venezuela, Romero shows off the hand-made oars he uses to propel his boat on Lake Maracaibo, one of the largest in America. South.

“We use sails because there is no fuel,” the nervous Romero told AFP after returning from his fishing trip.

He started working just before 6:00 a.m. and returned to shore at Los Puertos de Altagracia at 10:00 a.m. with seven medium-sized Croakers – a white-fleshed fish that is popular locally.

The 28-year-old sold five and brought two back to his wife and two-year-old daughter.

Fishermen in Lake Maracaibo often have to row their boats due to fuel shortages Luis BRAVO AFP

There was so little wind that he had to row back and forth across the lake, making it a long, arduous trip that only took a few minutes with an engine.

“It’s already normal to row or sail,” Romero said.

Most boats are adapted motorboats whose outboard motors have been removed and replaced with wooden masts and plastic sails, or propellers attached to a small motor.

These only need four liters of fuel compared to the 20 liters required for more powerful outboards.

– Constant oil spills –

Fuel has become a luxury in an area where few gas stations are stocked, while customer queues stretch for kilometers (miles) for the few who have it.

While fuel was virtually free for Venezuelans, it now costs $ 2 a liter on the black market, which is the only option for most people.

Fishermen return home with meager pickings after a morning on the lake
Fishermen return home with meager pickings after a morning on the lake Luis BRAVO AFP

Maduro’s government blames US sanctions preventing the South American country from buying fuel or unrefined oil.

Fishermen often borrow money from fishmongers to buy fuel “on credit” and then pay for it later with their daily earnings, which can be as high as $ 25 on “very good” days.

Sometimes, however, they can return to shore empty-handed but still with a bill to pay.

“Today I wasted fuel, I lost work and I didn’t catch anything, I just got tired,” said Jonathan, a father of six who returned with two shrimp and a meager handful of fish.

Fishermen usually sell their products in the old colonial town of Maracaibo before crossing the lake on their way home to Los Puertos de Altagracia, but if there isn’t enough wind they can get stranded.

The mismanagement of Venezuela’s oil infrastructure also means that spills are frequent and dark spots are visible on Lake Maraciabo as fishermen row or sail past them.

According to the NGO Azul Ambientalistas, there are 25,000 kilometers of oil pipelines in Lake Maraciabo, where oil was first discovered in 1914.

“The leaks are constant,” Gustavo Carrasquel of the NGO told AFP.

– ‘I will die here’ –

In Maracaibo itself, makeshift rickshaws with handcrafted textile roofs have replaced buses and taxis.

Manuel, who did not give his last name, drove a bus that could carry 50 people, now he has to pedal in a rickshaw that barely has room for two adult passengers.

“Due to the fuel issue the owner (of the bus) had to pull over and I found myself out of work,” said the 28-year-old driver as he repaired a flat tire.

He said it cost $ 200 a day to keep a bus on the road, but it was impossible to earn anything near that amount with passengers paying for their tickets in battered local currency.

The bolivar has been decimated by four years of hyperinflation and eight years of recession.

GDP has fallen by 80% since 2013 and 65% of people live in poverty.

Hender Urdaneta, 51, is a proud activist who supports the Socialist government often accused of authoritarianism and repression of dissent.

Maracaibo bus and taxi drivers had to trade ease of driving for the toil of pedaling due to fuel shortage in Venezuela
Maracaibo bus and taxi drivers had to trade ease of driving for the toil of pedaling due to fuel shortages in Venezuela Luis BRAVO AFP

Pedaling a pedicab has hurt his back, but he cannot afford to stop as he has to support his wife, who has lost a kidney and needs medication.

Despite the difficulties, he has no plans to leave the country or join the 1.8 million Venezuelans living in neighboring Colombia.

“I was born here and I will die here, fighting with my boots, like a homeland soldier, like a homeland activist, I work here with my cart,” he said.

Source link

]]>
https://candlesandcandlemaking.com/sailing-boats-and-bicycle-rickshaws-in-the-oil-rich-fuel-efficient-region-of-venezuela/feed/ 0
Blue Reflection: Second Light Trailer, 35 minutes of gameplay https://candlesandcandlemaking.com/blue-reflection-second-light-trailer-35-minutes-of-gameplay/ https://candlesandcandlemaking.com/blue-reflection-second-light-trailer-35-minutes-of-gameplay/#respond Mon, 09 Aug 2021 13:12:51 +0000 https://candlesandcandlemaking.com/blue-reflection-second-light-trailer-35-minutes-of-gameplay/

Publisher Koei Tecmo and developer Gust have released a new trailer and 35 minutes of live gameplay from Blue reflection: second light.

Blue reflection: second light is slated for PlayStation 4 and Switch on October 21 in Japan, and for PlayStation 4, Switch and PC via Steam on November 9 in North America and Europe. Learn more about the game here, here and here.

Take a look at the pictures below.

English

Japanese

  • 42:04 to 50:18 – Gameplay # 1
  • 51:47 to 1:11:03 – Gameplay # 2
  • 1:12:37 to 1:14:56 – Gameplay # 3
  • 1:15:40 to 1:20:54 – Gameplay # 4

Feedback policy

Comments are welcome and encouraged on Gematsu. However, we ask that you follow a simple set of guidelines:

  • Read the entire article before commenting.
  • Stay on topic.
  • No comments behind the wheelincluding trolling, baiting, or posting poop.
  • Know when not to comment. If you don’t care about a topic, you don’t need to comment.
  • No offensive comments. This includes abusive, threatening, pornographic, deceptive or defamatory content / language, as well as general harassment and individual attacks.
  • No begging for port.
  • No console wars.
  • Use spoiler tags when posting spoiler or NSFW content (non-nude only). For example: Woe to Leomon. Indicate the subject of the content outside of the spoiler tags.
  • Be respectful to other commentators. You don’t have to agree with each other, but debate politely. If you find that a reviewer is breaking this simple etiquette, don’t continue the conversation, just report it.

Gematsu reserves the right to modify or remove any comments without notice. This comments policy is subject to change at any time.

Source link

]]>
https://candlesandcandlemaking.com/blue-reflection-second-light-trailer-35-minutes-of-gameplay/feed/ 0
Cathie Wood, Meme-Stock champion who bet big on Tesla and Bitcoin, stands firm https://candlesandcandlemaking.com/cathie-wood-meme-stock-champion-who-bet-big-on-tesla-and-bitcoin-stands-firm/ https://candlesandcandlemaking.com/cathie-wood-meme-stock-champion-who-bet-big-on-tesla-and-bitcoin-stands-firm/#respond Fri, 06 Aug 2021 21:20:00 +0000 https://candlesandcandlemaking.com/cathie-wood-meme-stock-champion-who-bet-big-on-tesla-and-bitcoin-stands-firm/

Fans of fund manager Cathie Wood have created websites that track every investment move. They sell t-shirts with his photo in the style of Barack Obama’s “Hope” poster and with the ticker symbol of his flagship exchange-traded fund, ARK Innovation. On social media, they call her “Mamma Cathie”, “Aunt Cathie” and, in South Korea, “Money Tree”.

Behind the adoration lies her unchecked enthusiasm for a certain type of speculative investing: companies that generate little or no profit but which she says have the potential to change the world through “disruptive innovation”. His asset management firm, ARK Investment Management LLC, has put a lot of emphasis on trendy industries, including alternative energy companies, space exploration, and digital currencies.

Her interest in meme-worthy investing and her ubiquitous presence on Twitter and financial news channels pushed her alongside market influencers such as Tesla Inc. CEO Elon Musk, the venture capitalist. Chamath Palihapitiya and Barstool Sports founder David Portnoy, who use Twitter, YouTube and podcasts to get their messages straight to a new generation.

Last month, Ms Wood joined Mr Musk and Jack Dorsey, CEO of Twitter Inc. and Square Inc., for a one-hour virtual chat about the potential of bitcoin, which has been declining in value for months. “Think how explosive growth could be,” Ms. Wood said at one point.

Among the converts was rapper Busta Rhymes, aka Trevor Smith Jr., who tweeted he was “sold for bitcoin” a day after listening to the three talk about cryptocurrency.

Source link

]]>
https://candlesandcandlemaking.com/cathie-wood-meme-stock-champion-who-bet-big-on-tesla-and-bitcoin-stands-firm/feed/ 0
Public comment due regarding possible light rail service between Newark and Paterson https://candlesandcandlemaking.com/public-comment-due-regarding-possible-light-rail-service-between-newark-and-paterson/ https://candlesandcandlemaking.com/public-comment-due-regarding-possible-light-rail-service-between-newark-and-paterson/#respond Fri, 06 Aug 2021 13:00:58 +0000 https://candlesandcandlemaking.com/public-comment-due-regarding-possible-light-rail-service-between-newark-and-paterson/
The Paterson-Newark Transit Market Study offers three different options for a connection between counties. Graph via Passaic County.

Time is running out for people to submit comments on a report that focuses on ways to increase transit choices between two northern Jersey counties, such as the Newark Light Rail extension.

Passaic County Planning Council is accepting email submissions from members of the public until Sunday, August 8 regarding the Paterson-Newark Transit Market Study.

Slides presented at a virtual meeting last month indicated that the study found three options for creating new transit services between downtown Paterson and Newark, each of which would also serve Belleville, Nutley and Clifton if it was finally finished.

One of the choices outlined in the study would involve a light rail system that would start by using Newark’s light rail tracks from Newark Penn station to Newark Broad Street station before moving north near the Passaic River. . The streetcar would then travel further inland to the ON3 complex at the old Roche site in Nutley, then take Route 19, ending around Main Street in Paterson.

Paterson Newark Transit Market Research 2
Light Rail Option A. Chart via Passaic County.

Another possible streetcar route through Newark would follow the other line of the Newark Streetcar to Branch Brook Park before crossing east through the North Quarter and then heading north near the Passaic River.

Paterson Newark Transit Market Study 3
Light Rail Option B. Chart via Passaic County.

The third option would involve bus rapid transit instead of the light rail and use a route that would be similar to the first conceptual light rail route, but with some potential changes in Nutley.

Paterson Newark Transit Market Research 4
Bus rapid transit option. Graph via Passaic County.

If services are running on time, the total trip between Newark and Paterson would take 48 minutes with the first streetcar option, 51 minutes with the other streetcar option, and between 40 and 52 minutes with rapid transit by bus.

Currently, traveling between downtown Newark and downtown Paterson by public transportation requires either taking two New Jersey Transit trains and making a transfer at Secaucus Junction, or taking a local bus that stops frequently between the two cities.

The development of a new light rail service connecting two remote transit hubs in New Jersey is rare, but not unprecedented. The River Line was completed 17 years ago and connects Trenton to Camden, located over 30 miles southwest of the state capital.

If a plan for a light rail or bus rapid transit system were to be formally proposed between Essex County and Passaic County, there would still be many regulatory, environmental and financial barriers that would need to be removed for that a project progresses.

Until then, emails in response to the Paterson-Newark Transit Market Study can be sent to Andras Holzmann at [email protected] until this weekend. The Passaic County Planning Council is due to vote on whether or not to pass the study through the county master plan at its August 19 meeting.

Source link

]]>
https://candlesandcandlemaking.com/public-comment-due-regarding-possible-light-rail-service-between-newark-and-paterson/feed/ 0
Our Sun has a twin: this new star highlights the behavior of the Sun in its youth https://candlesandcandlemaking.com/our-sun-has-a-twin-this-new-star-highlights-the-behavior-of-the-sun-in-its-youth/ https://candlesandcandlemaking.com/our-sun-has-a-twin-this-new-star-highlights-the-behavior-of-the-sun-in-its-youth/#respond Thu, 05 Aug 2021 07:25:32 +0000 https://candlesandcandlemaking.com/our-sun-has-a-twin-this-new-star-highlights-the-behavior-of-the-sun-in-its-youth/

The Sun has fueled life on Earth for millions of years, burning to produce constant energy as astronomers study hidden surface mysteries and coronal differences. However, very little is known about its beginnings in our solar system and how it led to the emergence of life on the planet.

A new star detected by NASA could offer a glimpse of our own Sun and reveal how it all began. The young star, just 30 light years away, could function as a time machine and light up the Sun and tell us about its youth in the system as it developed over billions of years.

Research published in The Astrophysical Journal indicates that the study of the star provides more in-depth information on the impact of coronal emissions, stellar winds and atmospheric erosion of the first exoplanets of Venus, Earth, Mars. and young Earth.

At 4.65 billion years old, our Sun is a middle-aged star. (Photo: Nasa)

Our Sun has a twin

While it is impossible to go back in time and examine the conditions that favored life on Earth, studying the stars near our solar system can help improve knowledge about how life began. . The Milky Way has more than 100 billion stars, and one in ten shares characteristics with our Sun, and many are in the early stages of development.

Nicknamed Kappa 1 Ceti, the star is estimated to be between 600 and 750 million years old, roughly the same age as our Sun when life developed on Earth. According to NASA, because of its proximity, it’s like a neighbor who lives down the street next door (in cosmic terms). It also has a similar mass and surface temperature to our Sun, making it a “twin” of our young star around the time life first appeared on Earth, and an important target for study.

Researchers designed a model to predict some of the most important, but difficult to measure, features of Kappa 1 Ceti, drawing on the Hubble Space Telescope, NASA’s Transiting Exoplanet Survey satellite and NICER missions, and the XMM -Newton from ESA.

Source link

]]>
https://candlesandcandlemaking.com/our-sun-has-a-twin-this-new-star-highlights-the-behavior-of-the-sun-in-its-youth/feed/ 0
Study Sheds Light on Oral Vaccine Failure in Mouse Model of Chronic Bowel Disorder https://candlesandcandlemaking.com/study-sheds-light-on-oral-vaccine-failure-in-mouse-model-of-chronic-bowel-disorder/ https://candlesandcandlemaking.com/study-sheds-light-on-oral-vaccine-failure-in-mouse-model-of-chronic-bowel-disorder/#respond Wed, 04 Aug 2021 00:02:00 +0000 https://candlesandcandlemaking.com/study-sheds-light-on-oral-vaccine-failure-in-mouse-model-of-chronic-bowel-disorder/

A chronic intestinal disorder that occurs in areas with poor sanitation disrupts intestinal immune responses and impairs the effectiveness of the oral vaccine in a mouse model of the disease, according to research conducted by scientists at UPMC Children’s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine.

The report, published today in Immunity, is important because oral vaccines given by liquid drops in the mouth, such as polio and rotavirus vaccines, are particularly useful in low-income countries which may not have health workers trained in the administration of vaccines with needles. They can also stimulate better local immunity in the gut, which is essential for fighting diseases contracted from contaminated food and water -; including some of the same infections that contribute to bowel disorders, called environmental enteric dysfunction, or EED.

It is tragic that the exact vaccines that could help prevent EED are not working in children with the disease. ”

Timothy Hand, Ph.D., lead author of the study and Assistant Professor of Pediatrics and Immunology at the RK Mellon Institute for Pediatric Research at UPMC Children’s and Director of Pitt’s Gnotobiotic Core

EED is caused by malnutrition and chronic gastrointestinal infections caused by contaminated food and water. Infection with viruses, parasites or bacteria combined with a poor diet can trigger inflammation in the gut and damage finger-shaped projections called villi that help absorb nutrients from food.

“EED can affect anyone, but it’s a major problem in children because they’re still developing,” Hand said. “The result is that children with EED are stunted. They end up getting a smaller size. But perhaps more importantly, it can significantly affect brain development: these children have less cognitive ability. And this is an ongoing problem; you cannot restore that. development later in life. “

To learn more about the mechanisms behind oral vaccine failure, Hand and his team developed a mouse model of the disease. They induced EED-like symptoms by feeding rodents a diet deficient in fat and protein and inoculating them with a strain of E. coli bacteria that invades intestinal cells.

Like humans with the disease, EED mice exhibited growth retardation, changes in the composition of the gut microbiome, elevated intestinal inflammation, and shortened intestinal villi compared to control mice that were given a normal diet with sufficient fat. and protein or animals that have received a normal diet and bacteria or a poor diet without bacteria.

After giving the mice an oral vaccine, the researchers found that immune responses were severely compromised in people with EED. Vaccine-specific CD4 + T cells in the small intestine were approximately 18-fold lower than in control mice.

Further experiments indicated that oral vaccine failure in EED mice was mediated by their gut microbiome. In response to inflammation associated with the microbiome, regulatory T cells (Treg) accumulate in the small intestine of EED mice.

“Treg cells appear because there is too much inflammation and they help alleviate that inflammation,” Hand said. “But unfortunately, a side effect is that they prevent the local build-up of vaccine-specific CD4 + T cells.”

When the team used antibiotics to kill gut bacteria, the vaccine’s efficacy was restored in EED mice.

According to Hand, these findings support the idea that targeting the microbiome could help treat PAD and improve vaccine success in children.

“The judicious use of antibiotics in these children may be able to reset the microbiome of the small intestine, reduce inflammation in the small intestine, and reduce these Tregs,” he said.

EED is rare in resource-rich countries but common in poorer countries that lack sewage and sanitation systems. About 150 million children around the world live in conditions that put them at risk of contracting the disease.

“If we could put flush toilets and plumbing in the world, we wouldn’t have this disease,” Hand said. “What causes these chronic infections is that people drink contaminated water or that flies carry diseases from sewage to food.”

Going forward, Hand and his team plan to collaborate with researchers in countries where PED is a problem to better understand vaccine outcomes in children with this disease.

Source link

]]>
https://candlesandcandlemaking.com/study-sheds-light-on-oral-vaccine-failure-in-mouse-model-of-chronic-bowel-disorder/feed/ 0
Processor launches plan to replace old street lights https://candlesandcandlemaking.com/processor-launches-plan-to-replace-old-street-lights/ https://candlesandcandlemaking.com/processor-launches-plan-to-replace-old-street-lights/#respond Tue, 03 Aug 2021 08:00:17 +0000 https://candlesandcandlemaking.com/processor-launches-plan-to-replace-old-street-lights/

Clarksdale Public Utilities has approved the first phase of a plan to replace utility poles across the region by approving the offer of $ 149,775.81 from Gray’s Power Supply, LLC to carry out the work.

Gray’s Power Supply, LLC submitted the lowest bid of four companies. Bids ranged from $ 49,774.81 to DeSoto County Electric Inc.’s offer of $ 302,603.

Jeff Atwell of Atwell & Gent, PA, the Starkville engineering company for the project, spoke about the utility poles.

“Really what we need to do is complete a CPU team that is replacing the poles with outside contractors who will be caught up because we are late,” said Atwell. “Pole replacements and tree cutters are really bread and butter to keep the lights on. We have to catch up.

Atwell said there are around 5,000 poles that last an average of 40 years.

“What about poles that don’t need to be replaced? Said CPU Commissioner Donald Mitchell.

Atwell said he didn’t know the exact number of poles to replace, but the processor was behind schedule. He added that two and a half percent of utility poles should be replaced each year.

“I don’t believe this has been happening for a while,” Atwell said.

Atwell said the 40 to 60-year-old poles had not been replaced.

Mitchell referred to the 1994 ice storm.

“We replaced a lot of poles during the ice storm,” Mitchell said.

Atwell acknowledged that some of the poles have been replaced, but that could be a problem if the processor was short from 20 to 40 poles.

“It can get away from you quickly. It doesn’t sound like a lot in a particular year, but over a number of periods it catches up with you, ”Atwell said.

Other equipment issues were discussed during the meeting.

The Board approved the 2020 Wastewater Treatment Plant Erosion Control Contract Amendment Order Form to Construction Specialists, LLC for $ 93,975. The original amount was $ 89,030.

The board also approved the purchase of control equipment from Schweitzer Engineering Laboratories for the Power Connections Inc. substation for $ 26,520 as a sole source item.

Source link

]]>
https://candlesandcandlemaking.com/processor-launches-plan-to-replace-old-street-lights/feed/ 0